Sander, Kerstin and Kottke, Tim and Hoffend, Claas and Walter, Miriam and Weizel, Lilia and Camelin, Jean-Claude and Ligneau, Xavier and Schneider, Erich H. and Seifert, Roland and Schwartz, Jean-Charles and Stark, Holger (2010) First Metal-Containing Histamine H-3 Receptor Ligands. ORGANIC LETTERS, 12 (11). pp. 2578-2581. ISSN 1523-7060, 1523-7052
Full text not available from this repository. (Request a copy)Abstract
Iron-containing ligands targeting the human histamine H-3 receptor (hH(3)R) were prepared. The compounds contain ferrocene sandwich complexes coupled via different linkers to a basic hH(3)R antagonist/inverse agonist pharmacophore. In a click chemistry approach, a triazole was successfully inserted as a new linking element. Two ferrocenylmethylamines and a ferrocenyltriazole were the most affine hH(3)R ligands within this series, showing receptor binding in the nano- and subnanomolar concentration range.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHEMISTRY; ANTAGONISTS; AFFINITY; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Jul 2020 07:17 |
| Last Modified: | 28 Jul 2020 07:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24569 |
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