Adhesion of Candida albicans to various dental implant surfaces and the influence of salivary pellicle proteins

Buergers, Ralf and Hahnel, Sebastian and Reichert, Torsten E. and Rosentritt, Martin and Behr, Michael and Gerlach, Till and Handel, Gerhard and Gosau, Martin (2010) Adhesion of Candida albicans to various dental implant surfaces and the influence of salivary pellicle proteins. ACTA BIOMATERIALIA, 6 (6). pp. 2307-2313. ISSN 1742-7061, 1878-7568

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Abstract

Dental implants may be considered a potential reservoir for (re)infection with oral Candida albicans. Our aim was to evaluate initial fungal adhesion to three differentially textured titanium and one zirconia implant surface, and to correlate these findings to differences in specific surface characteristics (surface roughness (R-a) and surface free energy (SFE)). Additionally, we investigated the influence of salivary protein films and two pellicle proteins (mucin and albumin). Implant surfaces were characterized by perth-ometer (R-a) and goniometer (SFE) measurements. Implant specimens were rinsed with human whole saliva, mucin, albumin, or phosphate buffered saline and incubated in C. albicans suspension for 2.5 h. Adherent fungi were quantified by means of a bioluminometric assay. The lowest amount of fungal cells was found on sand-blasted titanium, whereas zirconia implants did not show any reduced potential to adhere C. albicans. The influence of the implant SFE on fungal biofilm formation appears to be more important than the influence of R-a. The protein mucin enhanced C albicans accumulation. In contrast, albumin is unlikely to be involved in the adhesion process of C albicans. (C) 2010 Published by Elsevier Ltd. on behalf of Acta Materialia Inc.

Item Type: Article
Uncontrolled Keywords: IN-VITRO; BACTERIAL-COLONIZATION; STREPTOCOCCUS-MUTANS; ORAL STREPTOCOCCI; RESIN MATERIALS; ADHERENCE; TITANIUM; VIVO; BIOFILM; ENAMEL; Dental implant; Fungal infection; Surface energy; Titanium; Zirconia
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie
Medicine > Lehrstuhl für Zahnärztliche Prothetik
Depositing User: Dr. Gernot Deinzer
Date Deposited: 28 Jul 2020 08:07
Last Modified: 28 Jul 2020 08:07
URI: https://pred.uni-regensburg.de/id/eprint/24570

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