Mueller-Richter, Urs D. A. and Dowejko, Albert and Peters, Silvia and Rauthe, Stephan and Reuther, Tobias and Gattenloehner, Stefan and Reichert, Torsten E. and Driemel, Oliver and Kuebler, Alexander C. (2010) MAGE-A antigens in patients with primary oral squamous cell carcinoma. CLINICAL ORAL INVESTIGATIONS, 14 (3). pp. 291-296. ISSN 1432-6981,
Full text not available from this repository. (Request a copy)Abstract
MAGE-A antigens are only expressed on tumor cells. The aim of this study was to identify their expression in patients with oral squamous cell carcinoma (OSCC). Forty-seven patients with primary OSCC was selected retrospectively. Histo-pathological sections were stained immunohistochemically with MAGE-A antibody 57B. The results were evaluated regarding tumor size (T), lymph-node metastasis (N), blood vessel infiltration (V), lymph vessel infiltration (L), grading (G), and sex. MAGE-A antigens were expressed in 55% of all patients. Expression increased with tumor size (T1 = 56%; T2 = 44%; T3 = 67%; T4 = 71%). Lymph-node metastasis had no influence (N0 and N1 about 50%). Tumors with blood and lymph vessel infiltration had higher expression (V0 = 50%; V1 = 100%; L0 = 46%; L1 = 71%). Less-differentiated tumors showed higher rates (G1 = 50%; G2 = 45%; G3 = 83%). OSCC in men were positive in 62% and in women in 38%. MAGE-A antigens are frequently expressed in OSCC. Their expression seems to increase with tumor dedifferentiation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CANCER-TESTIS ANTIGENS; CANCER/TESTIS ANTIGENS; TISSUE MICROARRAY; EXPRESSION; MELANOMA; HEAD; IMMUNOTHERAPY; GENES; TARGETS; VACCINATION; MAGE-A antigens; Immunotherapy; Oral squamous cell carcinoma; Tumor antigens |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Jul 2020 10:02 |
| Last Modified: | 28 Jul 2020 10:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24591 |
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