Synthesis of DNA with Spirobenzopyran as an Internal Covalent Modification

Beyer, Christoph and Wagenknecht, Hans-Achim (2010) Synthesis of DNA with Spirobenzopyran as an Internal Covalent Modification. SYNLETT (9). pp. 1371-1376. ISSN 0936-5214,

Full text not available from this repository. (Request a copy)

Abstract

The photochromic spirobenzopyran was incorporated as an internal modification into oligonucleotides by two different synthetic strategies: For the first route the spiropyran phosphoramidite was synthesized as a DNA building block, whereas for the second route the postsynthetic 'click'-type ligation was applied. Photoinduced ring opening of the chromophore could not be achieved in duplex DNA.

Item Type: Article
Uncontrolled Keywords: INTERCALATING NUCLEIC-ACIDS; CLICK CHEMISTRY; PHOTOCHROMIC SPIROPYRAN; CYCLOADDITION REACTION; THIAZOLE ORANGE; SOLID-PHASE; BASE; HYBRIDIZATION; AZOBENZENE; PHOTOREGULATION; oligonucleotide; molecular switch; click ligation; photochromism; phosphoramidite
Subjects: 500 Science > 540 Chemistry & allied sciences
Divisions: Chemistry and Pharmacy > Institut für Organische Chemie > Alumni or Retired Professors > Arbeitskreis Prof. Dr. Hans-Achim Wagenknecht
Depositing User: Dr. Gernot Deinzer
Date Deposited: 30 Jul 2020 07:21
Last Modified: 30 Jul 2020 07:21
URI: https://pred.uni-regensburg.de/id/eprint/24699

Actions (login required)

View Item View Item