Schaeffler, Andreas and Schoelmerich, Juergen (2010) Innate immunity and adipose tissue biology. TRENDS IN IMMUNOLOGY, 31 (6). pp. 228-235. ISSN 1471-4906
Full text not available from this repository. (Request a copy)Abstract
The understanding of the role of adipose tissue has changed from a lipid storage organ to an endocrine and immunologically active organ. Here, we summarize the evidence for an important role of adipose tissue in innate immunity. The review focuses on the expression and function of Toll-like receptors (TLRs) in adipocytes and on the role of adipose tissue macrophages. The dual activation of TLR4 in adipocytes by lipopolysaccharide and fatty acids represents a molecular gate that connects innate immunity with metabolism. Dichotomic molecules derived from ancient precursor molecules control metabolism and immune function. Visceral adipose tissue is infiltrated by macrophages in obesity, and there is local crosstalk between these two types of cells, leading to an inflammatory transformation of adipose tissue.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TOLL-LIKE-RECEPTOR; TUMOR-NECROSIS-FACTOR; N-TERMINAL KINASE; FREE FATTY-ACIDS; INSULIN-RESISTANCE; MACROPHAGE-INFILTRATION; 3T3-L1 ADIPOCYTES; FACTOR-ALPHA; CHRONIC INFLAMMATION; ENDOCRINE ORGAN; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 15 Apr 2020 10:00 |
| Last Modified: | 15 Apr 2020 10:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24701 |
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