Rieder, Florian and Biancani, Piero and Harnett, Karen and Yerian, Lisa and Falk, Gary W. (2010) Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 298 (5). G571-G581. ISSN 0193-1857, 1522-1547
Full text not available from this repository. (Request a copy)Abstract
Rieder F, Biancani P, Harnett K, Yerian L, Falk GW. Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis. Am J Physiol Gastrointest Liver Physiol 298: G571-G581, 2010. First published March 18, 2010; doi: 10.1152/ajpgi.00454.2009.-Gastroesophageal reflux disease (GERD) is one of the most common problems in clinical practice today. It is widely believed that functional and structural abnormalities of the gastroesophageal junction as well as an abnormal exposure to gastroduodenal contents are the main contributors to its pathogenesis. Novel findings of the inflammatory process in GERD suggest a far more complex process involving multifaceted inflammatory mechanisms. This review summarizes knowledge about the expression of inflammatory mediators in GERD and their potential cellular sources and provides an integrated concept of disease pathogenesis. In addition we evaluate the contribution of inflammatory mediators to well-known complications of GERD, namely motility abnormalities, fibrosis, and carcinogenesis. Novel findings regarding the pathophysiology of esophageal inflammation should enhance our understanding of GERD and its complications and provide new treatment insights.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PLATELET-ACTIVATING-FACTOR; PROTON-PUMP INHIBITOR; IN-VITRO MODEL; MICROVASCULAR ENDOTHELIAL-CELLS; OXIDASE NOX5-S EXPRESSION; OXIDATIVE DNA-DAMAGE; FACTOR-KAPPA-B; BARRETTS-ESOPHAGUS; BOWEL-DISEASE; PROINFLAMMATORY CYTOKINES; cytokines; motility; stricture; stenosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 15 Apr 2020 09:56 |
| Last Modified: | 15 Apr 2020 09:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24750 |
Actions (login required)
 |
View Item |
