Bosch, O. J. and Pfoertsch, J. and Beiderbeck, D. I. and Landgraf, R. and Neumann, I. D. (2010) Maternal Behaviour is Associated with Vasopressin Release in the Medial Preoptic Area and Bed Nucleus of the Stria Terminalis in the Rat. JOURNAL OF NEUROENDOCRINOLOGY, 22 (5). pp. 420-429. ISSN 0953-8194, 1365-2826
Full text not available from this repository. (Request a copy)Abstract
The neuropeptide arginine vasopressin was recently shown to be an important regulator of female social behaviour, including maternal care and aggression. A key brain site for vasopressin- as well as oxytocin-mediated maternal care is the medial preoptic area (MPOA). Together with the adjacent bed nucleus of the stria terminalis (BNST), these brain regions are considered to form a 'super-region' for maternal behaviour. In the present study, we investigated the vasopressin and oxytocin systems within the MPOA and the BNST during maternal care in lactating rats in more detail. Binding to V1a and oxytocin receptors in the BNST and to oxytocin receptors in the MPOA was increased in lactation. Furthermore, microdialysis revealed that vasopressin release significantly increased (MPOA) or tended to increase (BNST) during different phases of maternal care (i.e. with or without suckling stimulus). In support, manipulations of V1a receptors in the MPOA are known to alter maternal care. We now show that local injection of a selective V1a receptor antagonist bilaterally into the BNST did not affect maternal care, but reduced maternal aggression and tended to lower anxiety-related behaviour. The release of oxytocin did not change in any of the brain regions during maternal care. The results obtained indicate that locally-released vasopressin within the MPOA and the BNST is important for the maintenance of complex maternal behaviours, including maternal care and aggression, respectively.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NULLIPAROUS FEMALE RATS; ARGININE-VASOPRESSIN; MICROTUS-OCHROGASTER; RECEPTOR ANTAGONIST; CENTRAL AMYGDALA; LACTATING RATS; LATERAL SEPTUM; BINDING-SITES; OXYTOCIN; ANXIETY; arched back nursing; maternal aggression; microdialysis; oxytocin; V1a receptor antagonist |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Aug 2020 05:03 |
| Last Modified: | 03 Aug 2020 05:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24783 |
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