Rivera, Francisco J. and Steffenhagen, Carolin and Kremer, David and Kandasamy, Mahesh and Sandner, Beatrice and Couillard-Despres, Sebastien and Weidner, Norbert and Kuery, Patrick and Aigner, Ludwig (2010) Deciphering the Oligodendrogenic Program of Neural Progenitors: Cell Intrinsic and Extrinsic Regulators. STEM CELLS AND DEVELOPMENT, 19 (5). pp. 595-606. ISSN 1547-3287, 1557-8534
Full text not available from this repository. (Request a copy)Abstract
In the developing and adult CNS, neural stem/progenitor cells (NSPCs) and oligodendroglial progenitor cells (OPCs) follow an oligodendrogenic process with the aim of myelinating axons. This process is to a high degree regulated by an oligodendrogenic program (OPr) composed of intrinsic and extrinsic factors that modulate the different steps required for NSPCs to differentiate into myelinating oligodendrocytes. Even though NSPCs and OPCs are present in the diseased CNS and have the capacity to generate oligodendrocytes, sparse remyelination of axons constitutes a major constraint in therapies toward multiple sclerosis (MS) and spinal cord injury (SCI). Lack of pro-oligodendrogenic factors and presence of anti-oligodendrogenic activities are thought to be the main reasons for this limitation. Thus, molecular and cellular strategies aiming at remyelination and at targeting such pro- and anti-oligodendrogenic mechanisms are currently under investigation. The present review summarizes the current knowledge on the OPr; it implements our own findings on mesenchymal stem cell-derived pro-oligodendroglial factors and on the role of p57/kip2 in oligodendroglial differentiation. Moreover, it describes molecular and cellular approaches for the development of future therapies toward remyelination.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SPINAL-CORD-INJURY; CENTRAL-NERVOUS-SYSTEM; MESENCHYMAL STEM-CELLS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; OLFACTORY ENSHEATHING CELLS; IN-VITRO DIFFERENTIATION; SONIC HEDGEHOG PROMOTES; MYELIN-BASIC-PROTEIN; MARROW STROMAL CELLS; ADULT-RAT CNS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 15 Apr 2020 09:48 |
| Last Modified: | 15 Apr 2020 09:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24801 |
Actions (login required)
 |
View Item |
