Holtmann, Martin H. and Krummenauer, Frank and Claas, Christina and Kremeyer, Kristina and Lorenz, Dirk and Rainer, Olivia and Vogel, Iris and Boecker, Ulrich and Boehm, Stephan and Buening, Carsten and Duchmann, Rainer and Gerken, Guido and Herfarth, Hans and Luegering, Norbert and Kruis, Wolfgang and Reinshagen, Max and Schmidt, Jan and Stallmach, Andreas and Stein, Juergen and Sturm, Andreas and Galle, Peter R. and Hommes, Daan W. and D'Haens, Geert and Rutgeerts, Paul and Neurath, Markus F. (2010) Significant Differences Between Crohn's Disease and Ulcerative Colitis Regarding the Impact of Body Mass Index and Initial Disease Activity on Responsiveness to Azathioprine: Results from a European Multicenter Study in 1,176 Patients. DIGESTIVE DISEASES AND SCIENCES, 55 (4). pp. 1066-1078. ISSN 0163-2116,
Full text not available from this repository. (Request a copy)Abstract
In a survey comprising 1,176 patients with inflammatory bowel disease (IBD) we recently showed that azathioprine (AZA) beyond 4 years is beneficial in ulcerative colitis (UC) patients and in a subset of Crohn's disease (CD) patients. Here, we show for the first time that azathioprine responsiveness depends on body mass index (BMI). The relationship is reciprocal in UC and CD, with a better outcome in UC patients with a BMI<25 and in CD patients with a BMI>25. These observations are particularly interesting considering the evolving concept of a relationship between fatty metabolism and immune regulation. Additionally, we show that CD patients, but not UC patients, respond better to AZA when it is started in clinical remission. This observation may support data favouring a "hit hard and early'' regime in CD. Finally, we were able to demonstrate a decrease in the incidence of CD-related complications requiring surgery through treatment with AZA.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFLAMMATORY-BOWEL-DISEASE; RECEPTOR EXPRESSION; ABDOMINAL-TRAUMA; ADIPOSE-TISSUE; T-LYMPHOCYTES; TERM; INFLIXIMAB; MANAGEMENT; LEPTIN; TRIAL; Azathioprine; Crohn's disease; Ulcerative colitis; Disease activity; Body mass index |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Aug 2020 08:27 |
| Last Modified: | 03 Aug 2020 08:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24864 |
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