Weigert, Johanna and Obermeier, Florian and Neumeier, Markus and Wanninger, Josef and Filarsky, Michael and Bauer, Sabrina and Aslanidis, Charalampos and Rogler, Gerhard and Ott, Claudia and Schaeffler, Andreas and Schoelmerich, Juergen and Buechler, Christa (2010) Circulating Levels of Chemerin and Adiponectin Are Higher in Ulcerative Colitis and Chemerin Is Elevated in Crohn's Disease. INFLAMMATORY BOWEL DISEASES, 16 (4). pp. 630-637. ISSN 1078-0998, 1536-4844
Full text not available from this repository. (Request a copy)Abstract
Background: Chemerin is an adipokine that stimulates chemotaxis of cells of the innate immune system. Inflammatory bowel disease (IBD) is linked to an impaired immune response and, therefore, we hypothesized that systemic chemerin may be altered in IBD patients. Methods: Scrum was collected from patients with Crohn's disease (CD, 230 patients), ulcerative colitis (UC, 80 patients), and healthy controls (HC, 80 probands). Chemerin and adiponectin, which has already been measured in the serum of similar cohorts by others, were determined by enzyme-linked immunosorbent assay (ELISA). Results: Chemerin was elevated in IBD compared to HC and was higher in male CD than UC patients. Female and male CD patients had lower adiponectin levels compared to UC, and adiponectin was lower in female CD patients compared to female HC. Adiponectin tended to be higher in female and male UC patients compared to HC and this difference became significant in the whole study group. Correlations with disease activity were only found in males. Here, chemerin was higher in CD patients on remission but was reduced in UC nonactive disease. Adipo nectin was higher in UC with inactive disease. Treatment with corticosteroids was linked to elevated adiponectin in male CD patients and higher chemerin in female UC patients. Unlike adiponectin, which was elevated in female serum in all cohorts, chemerin was only higher in female UC patients. Conclusions: These findings further indicate potential regulatory functions of adipokines in intestinal inflammation that are partly gender-dependent and that may even be associated with the distinct immunopathogenesis of UC and CD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFLAMMATORY-BOWEL-DISEASE; DEXTRAN SULFATE SODIUM; METABOLIC SYNDROME; ADIPOSE-TISSUE; CELLS; MICE; DEFICIENCY; ADIPOKINE; RECEPTOR; INSULIN; immunomodulators; adiponectin; chemerin; gender |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Aug 2020 08:37 |
| Last Modified: | 03 Aug 2020 08:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24889 |
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