Gamulescu, Maria-Andreea and Helbig, Horst (2010) Lack of Therapeutic Effect of Ranibizumab in Fellow Eyes After Intravitreal Administration. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, 26 (2). pp. 213-216. ISSN 1080-7683,
Full text not available from this repository. (Request a copy)Abstract
Purpose: In patients with exudative age-related macular degeneration (AMD), intravitreal anti-vascular endothelial growth factor (VEGF) therapy can lead to stabilization and even improvement of visual acuity in the treated eye, as proven by multiple studies. Some case reports, however, also suspect an effect in the untreated fellow eye. Methods: Prospective case series of 26 patients treated with intravitreal ranibizumab injections in both eyes because of bilateral exudative AMD. In all patients, central retinal thickness (CRT) was measured by optical coherence tomography (OCT) in both eyes: before first treatment of the first eye, as well as 2 weeks later, just before first treatment of the second eye. Results: While mean CRT was significantly reduced in the treated first eye 2 weeks after intravitreal injection from 369.46 mu m (+/- 170.88) to 275.04 mu m (+/- 113.04), P = 0.0005, mean CRT in the untreated fellow eye increased significantly: from 349.08 mu m (+/- 118.93) to 403.46 mu m (+/- 173.14) 2 weeks later, P = 0.017. Conclusions: A therapeutic effect of ranibizumab in the untreated fellow eye could not be demonstrated. Overall, mean CRT in the untreated eye increased as would be expected for the normal course of this disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ENDOTHELIAL GROWTH-FACTOR; MACULAR DEGENERATION; BEVACIZUMAB AVASTIN; CEREBROVASCULAR ACCIDENTS; PHARMACOKINETICS; INJECTIONS; LUCENTIS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Aug 2020 08:53 |
| Last Modified: | 03 Aug 2020 08:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24921 |
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