Schreml, S. and Szeimies, R-M and Karrer, S. and Heinlin, J. and Landthaler, M. and Babilas, P. (2010) The impact of the pH value on skin integrity and cutaneous wound healing. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 24 (4). pp. 373-378. ISSN 0926-9959, 1468-3083
Full text not available from this repository. (Request a copy)Abstract
The process of cutaneous wound healing comprises three overlapping major phases: inflammation, proliferation and tissue remodelling. However, while mechanisms are studied scientifically on the cellular and subcellular level, there is still a lack of knowledge concerning basic clinical parameters like wound pH or pO(2). It could be proven that wound healing is affected by wound pH changes as they can lead to an inhibition of endogenous and therapeutically applied enzymes. Besides, the conformational structure of proteins and their functionality in wound healing is altered. Furthermore, the likelihood of bacterial colonization, which is a common problem in chronic wound pathogenesis, is affected by wound pH alterations. However, wound pH is rarely taken into account in current wound therapy strategies. A routinely performed monitoring of the wound pH and a subsequently adapted wound therapy would most possibly improve chronic wound therapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PERMEABILITY BARRIER HOMEOSTASIS; STRATUM-CORNEUM HYDRATION; SURFACE PH; STAPHYLOCOCCUS-AUREUS; PROPIONIBACTERIUM-ACNES; CONTINUOUS-CULTURE; GROWTH; EPIDERMIDIS; DISRUPTION; HUMANS; bacterial colonization; pH value; skin barrier; skin wound; wound closure |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Apr 2020 06:37 |
| Last Modified: | 14 Apr 2020 06:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24926 |
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