Minuth, Will W. and Denk, Lucia and Glashauser, Anne (2010) Towards a Guided Regeneration of Renal Tubules at a Polyester Interstitium. MATERIALS, 3 (4). pp. 2369-2392. ISSN 1996-1944
Full text not available from this repository. (Request a copy)Abstract
Stem/progenitor cells are promising candidates for a therapy of renal failure. However, sound knowledge about implantation and regeneration is lacking. Therefore, mechanisms leading from stem/progenitor cells into tubules are under research. Renal stem/progenitor cells were isolated from neonatal rabbit kidney and mounted between layers of polyester fleece. It creates an artificial interstitium and replaces coating by extracellular matrix proteins. Tubulogenic development is induced by aldosterone. Electron microscopy illuminates growth of tubules in close vicinity to polyester fibers. Tubules contain a differentiated epithelium. The spatial extension of tubules opens a new strategy for testing morphogenic drugs and biocompatible fleece materials.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STEM-CELLS; ARTIFICIAL INTERSTITIUM; DEVELOPING KIDNEY; ORGAN-CULTURE; INDUCTION; DIFFERENTIATION; TUBULOGENESIS; MORPHOGENESIS; INTEGRATION; INHIBITION; polyester fleece; artificial interstitium; kidney; stem/progenitor cells; regeneration; aldosterone |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Molekulare und zelluläre Anatomie > Prof. Dr. Will Minuth |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Apr 2020 06:39 |
| Last Modified: | 14 Apr 2020 06:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24927 |
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