Bierut, Laura J. and Agrawal, Arpana and Bucholz, Kathleen K. and Doheny, Kimberly F. and Laurie, Cathy and Pugh, Elizabeth and Fisher, Sherri and Fox, Louis and Howells, William and Bertelsen, Sarah and Hinrichs, Anthony L. and Almasy, Laura and Breslau, Naomi and Culverhouse, Robert C. and Dick, Danielle M. and Edenberg, Howard J. and Foroud, Tatiana and Grucza, Richard A. and Hatsukami, Dorothy and Hesselbrock, Victor and Johnson, Eric O. and Kramer, John and Krueger, Robert F. and Kuperman, Samuel and Lynskey, Michael and Mann, Karl and Neuman, Rosalind J. and Noethen, Markus M. and Nurnberger, John I. and Porjesz, Bernice and Ridinger, Monika and Saccone, Nancy L. and Saccone, Scott F. and Schuckit, Marc A. and Tischfield, Jay A. and Wang, Jen C. and Rietschel, Marcella and Goate, Alison M. and Rice, John P. (2010) A genome-wide association study of alcohol dependence. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107 (11). pp. 5082-5087. ISSN 0027-8424,
Full text not available from this repository. (Request a copy)Abstract
Excessive alcohol consumption is one of the leading causes of preventable death in the United States. Approximately 14% of those who use alcohol meet criteria during their lifetime for alcohol dependence, which is characterized by tolerance, withdrawal, inability to stop drinking, and continued drinking despite serious psychological or physiological problems. We explored genetic influences on alcohol dependence among 1,897 European-American and African-American subjects with alcohol dependence compared with 1,932 unrelated, alcohol-exposed, nondependent controls. Constitutional DNA of each subject was genotyped using the Illumina 1M beadchip. Fifteen SNPs yielded P < 10(-5), but in two independent replication series, no SNP passed a replication threshold of P < 0.05. Candidate gene GABRA2, which encodes the GABA receptor alpha 2 subunit, was evaluated independently. Five SNPs at GABRA2 yielded nominal (uncorrected) P < 0.05, with odds ratios between 1.11 and 1.16. Further dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying genetic variants associated with alcohol dependence.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ENVIRONMENTAL CONTRIBUTIONS; NICOTINE DEPENDENCE; LINKAGE DISEQUILIBRIUM; FAMILIAL TRANSMISSION; RISK-FACTORS; GABRA2 GENE; MALE TWINS; DRUG-USE; RECEPTOR; POPULATION; genetics; candidate genes |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Aug 2020 11:09 |
| Last Modified: | 03 Aug 2020 11:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24973 |
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