Felthaus, Oliver and Ernst, Wolfgang and Driemel, Oliver and Reichert, Torsten E. and Schmalz, Gottfried and Morsczeck, Christian (2010) TGF-beta stimulates glial-like differentiation in murine dental follicle precursor cells (mDFPCs). NEUROSCIENCE LETTERS, 471 (3). pp. 179-184. ISSN 0304-3940, 1872-7972
Full text not available from this repository. (Request a copy)Abstract
Dental stem cells such as dental follicle precursor cells (DFPCs) are capable of neural-like differentiation. However, compared to neuroectodermal progenitor cells such as murine retinal progenitor cells (mRPCs) they show only a limited capacity for glial cell differentiation. in this study we tested the influence of cell signaling on glial differentiation of mDFPCs. These cells were treated with inhibitors and activators of the Sonic hedgehog-, the Wnt/beta-Catenin-, and the TGF-beta-pathway. After incubation only an activation of the TGF-beta-pathway showed a remarkable glial-like cell differentiation. In contrast gene expression of neural cell markets was not regulated. In conclusion, TGF-beta improved glial-like, but not neural-like, differentiation of mDFPCs. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GFAP GENE PROMOTER; IN-VITRO; STEM-CELLS; NEURONAL DIFFERENTIATION; NEURAL DIFFERENTIATION; CULTURED ASTROCYTES; TRANSGENIC MICE; SONIC HEDGEHOG; EXPRESSION; GLIOGENESIS; Dental follicle cells; Glial differentiation; Transforming growth factor beta; Retinal progenitor cells; Glial fibrillar acidic protein |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Humangenetik Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Aug 2020 11:20 |
| Last Modified: | 03 Aug 2020 11:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24979 |
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