Weigert, Johanna and Neumeier, Markus and Wanninger, Josef and Filarsky, Michael and Bauer, Sabrina and Wiest, Reiner and Farkas, Stefan and Scherer, Marcus N. and Schaeffler, Andreas and Aslanidis, Charalampos and Schoelmerich, Juergen and Buechler, Christa (2010) Systemic chemerin is related to inflammation rather than obesity in type 2 diabetes. CLINICAL ENDOCRINOLOGY, 72 (3). pp. 342-348. ISSN 0300-0664, 1365-2265
Full text not available from this repository. (Request a copy)Abstract
P>Background The adipokine chemerin modulates the function of innate immune cells and may link obesity and inflammation, and therefore, a possible relation of chemerin to inflammatory proteins in obesity and type 2 diabetes (T2D) was analysed. As visceral fat contributes to systemic inflammation, chemerin was measured in portal venous (PVS), hepatic venous (HVS) and systemic venous (SVS) blood of patients with liver cirrhosis. Patients and methods Systemic chemerin was determined by ELISA in the serum of normal-weight, overweight and T2D males, in the serum of T2D patients of both sexes, and in PVS, HVS and SVS of patients with liver cirrhosis. Results Circulating chemerin was similar in T2D and obese individuals but was significantly elevated in both cohorts compared to normal-weight individuals. Chemerin positively correlated with leptin, resistin and C-reactive protein (CRP). In T2D, chemerin was similar in male and female patients and increased in patients with elevated CRP. Chemerin was similar in PVS and SVS, indicating that visceral fat is not a major site of chemerin synthesis. Higher levels of chemerin in HVS demonstrate that chemerin is also released by the liver. Conclusions Visceral fat is not a major site of chemerin release, and elevated systemic levels of chemerin in obesity and T2D seem to be associated with inflammation rather than body mass index.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VISCERAL ADIPOSE-TISSUE; METABOLIC SYNDROME; RISK-FACTORS; ADIPOKINE; DISEASE; RECEPTOR; LEPTIN; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Aug 2020 04:46 |
| Last Modified: | 05 Aug 2020 04:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25020 |
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