Walitza, Susanne and Wendland, Jens R. and Gruenblatt, Edna and Warnke, Andreas and Sontag, Thomas A. and Tucha, Oliver and Lange, Klaus W. (2010) Genetics of early-onset obsessive-compulsive disorder. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 19 (3). pp. 227-235. ISSN 1018-8827
Full text not available from this repository. (Request a copy)Abstract
Obsessive-compulsive disorder (OCD) is characterized by recurrent, intrusive and disturbing thoughts as well as by repetitive stereotypic behaviors. Epidemiological data are similar in children and adults, i.e., between 1 and 3% of the general population suffer from OCD. Children with OCD are often seriously impaired in their development. OCD, especially of early onset, has been shown to be familial. Several candidate genes of predominantly neurotransmitter systems have been analyzed and a total of three genome-wide linkage scans have been performed until now. Analyses of candidate genes in linkage regions have not provided evidence for their involvement in OCD, with the exception of the glutamate transporter gene SLC1A1 on 9p24. Genome-wide association analyses are in progress and the results will promote further independent replication studies. The consideration of subtypes regarding age of onset, symptom dimensions and/or comorbid disorders is needed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 5-HT2A PROMOTER POLYMORPHISM; SEROTONIN TRANSPORTER; TRANSMISSION DISEQUILIBRIUM; PSYCHIATRIC-DISORDERS; PEDIATRIC PROBANDS; FAMILY; ASSOCIATION; ADOLESCENTS; CHILDREN; LINKAGE; Obsessive-compulsive disorder; Serotonin; Glutamate transporter gene; Early onset; Brain-derived neurotrophic factor |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange |
| Depositing User: | Petra Gürster |
| Date Deposited: | 09 Apr 2020 12:21 |
| Last Modified: | 09 Apr 2020 12:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25028 |
Actions (login required)
 |
View Item |
