Sander, K. and Kottke, T. and Proschak, E. and Tanrikulu, Y. and Schneider, E. H. and Seifert, R. and Schneider, G. and Stark, H. (2010) Lead identification and optimization of diaminopyrimidines as histamine H-4 receptor ligands. INFLAMMATION RESEARCH, 59. pp. 249-251. ISSN 1023-3830,
Full text not available from this repository. (Request a copy)Abstract
The human histamine H-4 receptor (hH(4)R) is a promising new target in the therapy of inflammatory or immune system diseases. For the development of new hH(4)R ligands, a broad virtual screening was performed and two hits were identified. Their annelated heterocyclic core was optimized with regard to affinity and potency. Pharmacological characterization of the resulting diaminopyrimidines revealed different agonist and antagonist properties within the same scaffold.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; Histamine H-4 receptor; Aminopyrimidine; Purine; Inflammation; Structure-affinity/efficacy-relationships |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Aug 2020 07:34 |
| Last Modified: | 05 Aug 2020 07:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25078 |
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