Weigert, Johanna and Neumeier, Markus and Wanninger, Josef and Bauer, Sabrina and Farkas, Stefan and Scherer, Marcus N. and Schnitzbauer, Andreas and Schaeffler, Andreas and Aslanidis, Charalampos and Schoelmerich, Juergen and Buechler, Christa (2010) Serum Galectin-3 Is Elevated in Obesity and Negatively Correlates with Glycosylated Hemoglobin in Type 2 Diabetes. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 95 (3). pp. 1404-1411. ISSN 0021-972X, 1945-7197
Full text not available from this repository. (Request a copy)Abstract
Context: Adipocytes synthesize galectin-3 whose deficiency protects from inflammation associated with metabolic diseases. We aimed to study circulating galectin-3 in obesity and type 2 diabetes (T2D). Study Design: Galectin-3 was measured by ELISA in the serum of male normal-weight and overweight controls and T2D patients and in T2D patients of both sexes. Because visceral fat contributes to systemic inflammation, galectin-3 was analyzed in paired samples of human and rodent sc and visceral adipose tissue. Visceral adipose tissue adipokines are released to the portal vein, and galectin-3 was analyzed in portal, hepatic, and systemic venous serum (PVS, HVS, and SVS, respectively) of patients with liver cirrhosis and in patients who underwent surgery for nonhepatic diseases. The effect of metformin on adipocyte galectin-3 was analyzed by immunoblot. Results: Circulating galectin-3 was similarly elevated in T2D and obesity compared with normal-weight individuals and revealed a body mass index-dependent positive correlation with leptin, resistin, IL-6, and age. In T2D patients, galectin-3 was increased in serum of patients with elevated C-reactive protein and negatively correlated with glycated hemoglobin. Metformin treatment was associated with lower systemic galectin-3. Reduced galectin-3 in metformin-incubated human adipocytes indicated that low galectin-3 may be a direct effect of this drug. Galectin-3 was higher in PVS compared with HVS and SVS, suggesting that the splanchnic region is a major site of galectin-3 synthesis. Low galectin-3 in HVS compared with PVS demonstrated hepatic removal. Conclusions: Systemic galectin-3 is elevated in obesity and negatively correlates with glycated hemoglobin in T2D patients, pointing to a modifying function of galectin-3 in human metabolic diseases. (J Clin Endocrinol Metab 95: 1404-1411, 2010)
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FATTY LIVER-DISEASE; ADIPOSE-TISSUE; ATHEROSCLEROTIC LESIONS; TARGETED DISRUPTION; METABOLIC SYNDROME; RISK-FACTORS; INFLAMMATION; ADIPONECTIN; EXPRESSION; MICE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Aug 2020 08:37 |
| Last Modified: | 05 Aug 2020 08:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25083 |
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