Castrop, Hayo (2010) Genetically modified mice-successes and failures of a widely used technology. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 459 (4). pp. 557-567. ISSN 0031-6768,
Full text not available from this repository. (Request a copy)Abstract
Genetically modified mice, created by random integration of a transgene into the genome or by targeted mutation of a specific gene, have proven to be extremely powerful tools for studying gene function in vivo. In this article, we give (1) a short overview of the traditional methods in mouse transgenesis and (2) a discussion of the problems with these methods, (3) more recent methods that were developed to overcome these problems, and (4) an outlook on future directions in gene targeting.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ZINC-FINGER NUCLEASES; SITE-SPECIFIC RECOMBINATION; EMBRYONIC STEM-CELLS; RNA INTERFERENCE; MAMMALIAN-CELLS; GENE-EXPRESSION; TUBULOGLOMERULAR FEEDBACK; SACCHAROMYCES-CEREVISIAE; CAENORHABDITIS-ELEGANS; CONDITIONAL KNOCKOUT; Transgenic mouse; RNA editing; Gene expression; Phenotype; Embryo |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Wolf Hayo Castrop |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Aug 2020 04:46 |
| Last Modified: | 06 Aug 2020 04:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25120 |
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