Gestreau, Christian and Heitzmann, Dirk and Thomas, Joerg and Dubreuil, Veronique and Bandulik, Sascha and Reichold, Markus and Bendahhou, Said and Pierson, Patricia and Sterner, Christina and Peyronnet-Roux, Julie and Benfriha, Cherif and Tegtmeier, Ines and Ehnes, Hannah and Georgieff, Michael and Lesage, Florian and Brunet, Jean-Francois and Goridis, Christo and Warth, Richard and Barhanin, Jacques (2010) Task2 potassium channels set central respiratory CO2 and O-2 sensitivity. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107 (5). pp. 2325-2330. ISSN 0027-8424,
Full text not available from this repository. (Request a copy)Abstract
Task2 K+ channel expression in the central nervous system is surprisingly restricted to a few brainstem nuclei, including the retrotrapezoid (RTN) region. All Task2-positive RTN neurons were lost in mice bearing a Phox2b mutation that causes the human congenital central hypoventilation syndrome. In plethysmography, Task2(-/-) mice showed disturbed chemosensory function with hypersensitivity to low CO2 concentrations, leading to hyperventilation. Task2 probably is needed to stabilize the membrane potential of chemoreceptive cells. In addition, Task2(-/-) mice lost the long-term hypoxia-induced respiratory decrease whereas the acute carotid-body-mediated increase was maintained. The lack of anoxia-induced respiratory depression in the isolated brainstem-spinal cord preparation suggested a central origin of the phenotype. Task2 activation by reactive oxygen species generated during hypoxia could silence RTN neurons, thus contributing to respiratory depression. These data identify Task2 as a determinant of central O-2 chemoreception and demonstrate that this phenomenon is due to the activity of a small number of neurons located at the ventral medullary surface.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DOMAIN K+ CHANNEL; VENTILATORY RESPONSE; IN-VITRO; RHYTHM GENERATOR; NEURONS; MODULATION; MECHANISMS; HYPOXIA; OXYGEN; MEDULLA; breathing; central chemoreceptors; K2P; KCNK5; ventral medullary surface |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Aug 2020 08:48 |
| Last Modified: | 07 Aug 2020 08:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25164 |
Actions (login required)
 |
View Item |
