Pongratz, Georg and Straub, Rainer H. (2010) The B cell, arthritis, and the sympathetic nervous system. BRAIN BEHAVIOR AND IMMUNITY, 24 (2). pp. 186-192. ISSN 0889-1591, 1090-2139
Full text not available from this repository. (Request a copy)Abstract
The pathogenesis of rheumatoid arthritis (RA) is still an unresolved puzzle. Many factors and inflammatory cells play together to initiate a chronic inflammatory process that, if untreated, leads to complete destruction of involved joints. Recent success in treating severe forms of RA with B cell-depleting or modifying agents revived the concept that the B cell might play a pivotal role in the pathogenesis of some forms of arthritis. However, the rather unspecific treatment approach affecting all B cells, no matter if autoreactive or not, leads to potential harmful side-effects, e.g., severe infections. Therefore, finding regulatory systems that more specifically modulate B cell function is important to improve current treatment options. One such regulatory system is the sympathetic nervous system (SNS), which is known to modulate B cell function, but also profoundly influences arthritis development and severity. This review develops the hypothesis that the SNS via modulating B cell function influences arthritis development and progression. For this purpose data is presented that shows (1) how the SNS influences B cell function, (2) how the SNS influences arthritis development and severity, and (3) how B cells are involved in the disease process with an emphasis on possible contact points for SNS neuromodulation. (C) 2009 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COLLAGEN-INDUCED ARTHRITIS; ANTIGEN-PRESENTING CELLS; IGA-RHEUMATOID-FACTOR; NEUROPEPTIDE-Y NPY; RAT VAS-DEFERENS; IN-VIVO; T-CELLS; LYMPH-NODES; TRANSCRIPTIONAL ACTIVATION; SYNOVIAL TISSUE; B cell; Rheumatoid arthritis; Sympathetic nervous system |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 09 Apr 2020 12:10 |
| Last Modified: | 09 Apr 2020 12:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25177 |
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