Hennig, Christian and Baumann, Ulrich and Ilginus, Claudia and Horneff, Gerd and Foell, Juergen and Hansen, Gesine (2010) Successful treatment of autoimmune and lymphoproliferative complications of patients with intrinsic B-cell immunodeficiencies with Rituximab. BRITISH JOURNAL OF HAEMATOLOGY, 148 (3). pp. 445-448. ISSN 0007-1048,
Full text not available from this repository. (Request a copy)Abstract
P>The heterogeneous group of primary immunodeficiencies requires personalized diagnosis and therapy to acheive an optimal outcome for each patient. This was exemplified by two patients with intrinsic B-cell class-switch defects (subclass of Hyper-IgM syndromes), where lymphoproliferation and autoimmunity determined the clinical course for many years due to lack of exact diagnosis. Based on genetics or a novel functional diagnostic approach, a definite individual diagnosis was established for each patient and they started Rituximab therapy. Autoimmune phenomena and generalized lymphadenopathy disappeared and remained well controlled during the observation period (3-4 years) without adverse effects. Quality of life increased remarkably in both patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DEFICIENCY CAUSES; DISEASE; Hyper-IgM syndrome; class-switch defect; Rituximab; primary immunodeficiency; iterative Chip-based cytometry |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Aug 2020 09:36 |
| Last Modified: | 07 Aug 2020 09:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25179 |
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