Wenke, Ann-Kathrin and Bosserhoff, Anja K. (2010) Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development. FEBS JOURNAL, 277 (4). pp. 894-902. ISSN 1742-464X, 1742-4658
Full text not available from this repository. (Request a copy)Abstract
During embryogenesis, most of the mammalian skeletal system is preformed as cartilaginous structures that ossify later. The different stages of cartilage and skeletal development are well described, and several molecular factors are known to influence the events of this enchondral ossification, especially transcription factors. Members of the AP-2 family of transcription factors play important roles in several cellular processes, such as apoptosis, migration and differentiation. Studies with knockout mice demonstrate that a main function of AP-2s is the suppression of terminal differentiation during embryonic development. Additionally, the specific role of these molecules as regulators during chondrogenesis has been characterized. This review gives an overview of AP-2s, and discusses the recent findings on the AP-2 family, in particular AP-2 alpha, AP-2 beta, and AP-2 epsilon, as regulators of cartilage and skeletal development.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NEURAL CREST DEVELOPMENT; AUTOSOMAL SEX REVERSAL; SENSITIVE PROTEIN GENE; SRY-RELATED GENE; DNA-BINDING; FACTOR AP-2-ALPHA; RETINOIC ACID; EPITHELIAL-CELLS; POLY(ADP-RIBOSE) POLYMERASE-1; CHONDROCYTE DIFFERENTIATION; AP-2; cartilage; chondrogenesis; limb; transcriptional regulation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 09 Apr 2020 10:38 |
| Last Modified: | 09 Apr 2020 10:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25207 |
Actions (login required)
 |
View Item |
