Waldherr, Martin and Nyuyki, Kewir and Maloumby, Rodrigue and Bosch, Oliver J. and Neumann, Inga D. (2010) Attenuation of the neuronal stress responsiveness and corticotrophin releasing hormone synthesis after sexual activity in male rats. HORMONES AND BEHAVIOR, 57 (2). pp. 222-229. ISSN 0018-506X,
Full text not available from this repository. (Request a copy)Abstract
Beneficial effects of sexual activity and mating on the responsiveness to environmental stress can be observed in humans and other mammalian species alike, but the underlying neurobiological mechanisms are largely unknown. Sexual activity and mating with a receptive female has recently been shown to reduce the subsequent emotional stress response via activation of the brain oxytocin system. Therefore, we investigated the neuronal and hormonal responses to an acute stressor (forced swimming) after mating in male rats. Attenuation of the stress-induced increase of c-fos and CRH mRNA expression within the hypothalamic paraventricular nucleus 4 h after mating revealed that sexual activity reduced neuronal reactivity in this region. However, this effect was independent of oxytocin as oxytocin receptor blockade, by central administration of an oxytocin receptor antagonist, after mating did not prevent the reduced expression of c-fos mRNA in response to stressor exposure. Mating itself stimulated corticotrophin (ACTH) and corticosterone secretion, which was absent in males after contact with an unreceptive female (non-mated group). However, ACTH and corticosterone responses to forced swimming applied either 45 min or 4 h after female contact were similar between mated and non-mated males. These findings provide evidence for a stress-protective effect of sexual activity and mating in male rats and for dissociation between neuronal and neuroendocrine stress responses. (c) 2009 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FOS MESSENGER-RNA; C-FOS; PARAVENTRICULAR NUCLEUS; MALE-MICE; GENE-EXPRESSION; ENDOCRINE RESPONSES; PRENATAL STRESS; BRAIN OXYTOCIN; SOCIAL STRESS; FEMALE RATS; ACTH; Corticosterone; Forced swimming; Intracerebroventricular; Mating; Oxytocin |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Aug 2020 12:03 |
| Last Modified: | 07 Aug 2020 12:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25215 |
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