Rieder, Florian and Schleder, Stephan and Wolf, Alexandra and Dirmeier, Andrea and Strauch, Ulrike and Obermeier, Florian and Lopez, Rocio and Spector, Larissa and Fire, Ella and Yarden, Jennifer and Rogler, Gerhard and Dotan, Nir and Klebl, Frank (2010) Association of the Novel Serologic Anti-glycan Antibodies Anti-laminarin and Anti-chitin with Complicated Crohn's Disease Behavior. INFLAMMATORY BOWEL DISEASES, 16 (2). pp. 263-274. ISSN 1078-0998, 1536-4844
Full text not available from this repository. (Request a copy)Abstract
Background: We tested a panel of novel serological anti-glycan antibodies including the previously unpublished anti-laminarin IgA (Anti-L) and anti-chitin IgA (Anti-C) carbohydrate antibodies for the presence in Crohn's disease (CD) patients, diagnosis and differentiation of CD, association with complicated disease behavior, and marker stability over time. Methods: The presence of Anti-L, Anti-C, anti-chitobioside IgA (ACCA), anti-laminaribioside IgG (ALCA), anti-mannobioside IgG (AMCA), and anti-Saccaromyces cervisiae IgG (gASCA) carbohydrate antibodies were tested in serum samples from 824 participants (363 CID, 130 ulcerative colitis [UC], 74 other gastrointestinal diseases, and 257 noninflammatory bowel/gastrointestinal disease controls) of the German IBD-network by enzyme-linked innnunosorbent assay (ELISA; Glycominds, Lod, Israel) and for perinuclear antineutrophil cytoplasmic antibody (pANCA) by immunofluorescence. Results: In all, 77.4% of the CID patients were positive for at least I of the anti-glycan antibodies. gASCA or the combination of gASCA/pANCA remained most accurate for the diagnosis of CID, but the combined use of the antibodies improved differentiation of CD from UC. Several single markers as well as an increasing antibody response were independently linked to a severe disease phenotype, as shown for the occurrence of complications, CID-related surgery, early disease onset, and ileal disease location. This was observed for both quantitative and qualitative antibody responses. The antibody status remained stable over time in most IBD patients. Conclusions: A panel of anti-glycan antibodies including the novel Anti-L and Anti-C may aid in differentiation of CID fro, UC, is associated with complicated CID behavior and IBD-related surgery, and is stable over time in a large patient cohort.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFLAMMATORY-BOWEL-DISEASE; ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES; CEREVISIAE MANNAN ANTIBODIES; SACCHAROMYCES-CEREVISIAE; NOD2/CARD15 GENOTYPE; MICROBIAL ANTIGENS; ULCERATIVE-COLITIS; CLINICAL-COURSE; FOLLOW-UP; MARKERS; serum antibody; Crohn's; glycan; Anti-L; Anti-C |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Aug 2020 05:43 |
| Last Modified: | 10 Aug 2020 05:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25218 |
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