Stoecklein, Nikolas H. and Klein, Christoph A. (2010) Genetic disparity between primary tumours, disseminated tumour cells, and manifest metastasis. INTERNATIONAL JOURNAL OF CANCER, 126 (3). pp. 589-598. ISSN 0020-7136, 1097-0215
Full text not available from this repository. (Request a copy)Abstract
Recent genetic analyses of paired samples from primary tumours and disseminated tumour cells have uncovered a bewildering genetic disparity. It was therefore proposed that ectopically residing tumour cells disseminate early and develop independently into metastases parallel to the primary tumour. Alternatively, these cells may represent an irrelevant cell population unable to spawn metastases whereas only cells that disseminated late in primary tumour development (which therefore are similar to the primary tumour) will form manifest metastasis. Here, we review comparative analyses of paired samples from primary tumours and disseminated tumour cells or primary tumours and metastases. The data demonstrate a striking disparity, questioning the use of primary tumours as surrogate for the genetics of systemic cancer. In the era of molecular therapies that build upon genetic defects of tumour cells, these data call for a direct diagnostic pathology of systemic cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LYMPH-NODE METASTASES; COMPARATIVE GENOMIC HYBRIDIZATION; PRIMARY COLORECTAL CARCINOMAS; HER2-POSITIVE BREAST-CANCER; P53 MUTATIONS; LUNG-CANCER; BONE-MARROW; BARRETTS ADENOCARCINOMA; CHROMOSOMAL ALTERATIONS; ADJUVANT CHEMOTHERAPY; metastasis; disseminated tumour cells; clonality; cancer genetics; micrometastasis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 09 Apr 2020 10:32 |
| Last Modified: | 09 Apr 2020 10:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25220 |
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