Dorn, Christoph and Weiss, Thomas S. and Heilmann, Joerg and Hellerbrand, Claus (2010) Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells. INTERNATIONAL JOURNAL OF ONCOLOGY, 36 (2). pp. 435-441. ISSN 1019-6439, 1791-2423
Full text not available from this repository. (Request a copy)Abstract
Xanthohumol, the major prenylated chalcone found in hops, is well known to exert anti-cancer effects, but information regarding the impact on hepatocellular carcinoma (HCC) cells and potential adverse effects on non-tumorous hepatocytes is limited. Here, we show that xanthohumol at a concentration of 25 mu M induced apoptosis in two HCC cell lines (HepG2 and Huh7). Furthermore, xanthohumol repressed proliferation and migration, as well as TNF induced NF-kappa B activity and interleukin-8 expression in both cell lines at even lower concentrations. In contrast, xanthohumol concentrations up to 100 mu M did not affect viability of primary human hepatocytes ire vitro. In summary, our data showed that xanthohumol can ameliorate different pro-tumorigenic mechanisms known to promote HCC progression, indicating its potential as promising therapeutic agent that selectively affects cancer cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMULUS-LUPULUS L.; HUMAN LIVER-MICROSOMES; IL-8 GENE-EXPRESSION; KAPPA-B; EPITHELIAL-CELLS; HUMAN COLON; CANCER; FLAVONOIDS; APOPTOSIS; HEPATOCYTES; xanthohumol; chalcone; hepatocellular carcinoma; apoptosis; proliferation; migration |
| Subjects: | 600 Technology > 610 Medical sciences Medicine 600 Technology > 615 Pharmacy |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin I Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Aug 2020 06:07 |
| Last Modified: | 10 Aug 2020 06:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25221 |
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