Gruenhage, Frank and Nattermann, Jacob and Gressner, Olav A. and Wasmuth, Hermann E. and Hellerbrand, Claus and Sauerbruch, Tilman and Spengler, Ulrich and Lammert, Frank (2010) Lower copy numbers of the chemokine CCL3L1 gene in patients with chronic hepatitis C. JOURNAL OF HEPATOLOGY, 52 (2). pp. 153-159. ISSN 0168-8278,
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Background & Aims: Recently, variation of gene copy numbers was recognized as a novel type of common genetic diversity, but its impact oil vital hepatitis is unknown. Here, we determine the influence of copy number variation on the susceptibility and disease severity in hepatitis C Virus (HCV) infection, investigating Copy number Variants (CNVs) of the chemokine CCL3L1 gene, which encodes a potent CCR5 ligand. Methods: CNVs were determined in 254 patients with chronic hepatitis C, 144 HCV/HIV co-infected patients, and 2 10 HCV negative controls, using quality-controlled real-time fluorescent dye-labeled quantitative PCR. Liver biopsies were obtained from HCV infected patients. Results:Copy numbers of the CCL3L1 gene range from 0 to 12 (mean 2.7 +/- 1.4 copies). Patients with two or less copies are over-represented in the HCV infected cohort compared to HCV negative controls (odds ratio [OR] 1.54: p = 0.02). CCL31 copies are shifted to lower numbers in HCV infected patients (means 2.6 vs. 2.9 in controls; p = 0.011). HCV/HIV co-infected patients carry even lower CCL3L1 copy numbers compared to controls (means 2.2 vs. 2.9; p<0.001), with a higher proportion of patients possessing two or less copies (OR = 3.42; p < 0.001). No association was detected between CCL3L1 copy numbers and histological grades of inflammation or stages of fibrosis. Conclusions: Lower CCL3L1 gene copy number compared to the Population median is associated with chronic hepatitis C. Copy number variation of host genes represents a novel class of genetic diversity associated with viral hepatitis. (C) 2009 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HIV-1 INFECTION; VIRUS-INFECTION; T-LYMPHOCYTES; HCV INFECTION; HUMAN GENOME; POLYMORPHISM; INDIVIDUALS; DISEASE; LIVER; INFLAMMATION; Association study; Complex disease; Gene duplication; Gene variant; Hepatitis C virus; Polymorphism; Susceptibility factor |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Aug 2020 06:34 |
| Last Modified: | 10 Aug 2020 06:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25227 |
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