Zuber-Jerger, Ina and Mueller, Adelheid and Kullmann, Frank and Gelbmann, Cornelia M. and Endlicher, Esther and Mueller-Ladner, Ulf and Fleck, Martin (2010) Gastrointestinal manifestation of systemic sclerosis-thickening of the upper gastrointestinal wall detected by endoscopic ultrasound is a valid sign. RHEUMATOLOGY, 49 (2). pp. 368-372. ISSN 1462-0324,
Full text not available from this repository. (Request a copy)Abstract
Objective. Gastrointestinal (GI) tract involvement has been observed in the majority of patients with SSc. This has been attributed to an accumulation of extracellular matrix within the GI walls. We visualized the walls of the oesophagus, stomach and duodenum with its layers and measured the thickness in SSc patients and control patients utilizing endoscopic ultrasound (EUS). Methods. Twenty-five SSc patients and 25 controls were evaluated. In addition to analysis of clinical symptoms, endoscopy and EUS (20-MHz miniprobe) were performed. The thickness of the complete wall was measured, and the mucosa, submucosa and muscularis were evaluated separately. Results. Clinical symptoms of SSc patients were dysphagia (14/25) and heartburn (19/25). Endoscopic findings were hiatal hernia (16/25), oesophagitis (6/25), amotility (19/25) and a dehiscent pylorus (15/25). In comparison with controls, SSc patients had significantly thicker oesophageal [SSc 1.619 (0.454) mm, control 1.392 (0.333) mm; P = 0.025], antral [SSc 1.876 (0.635) mm, control 1.599 (0.291) mm; P = 0.029] and duodenal [SSc 1.730 (0.522) mm, control 1.525 (0.222) mm; P = 0.039] walls. Predominantly, submucosa and muscularis were significantly thicker in SSc patients. The presence of dysphagia or amotility was significantly associated with the thickening of the GI walls. Conclusions. The EUS revealed a significant thickening of the walls of the upper GI tract in SSc patients. Predominantly, the submucosa and muscularis are enlarged. These results strengthen the hypothesis that increased matrix deposition is an important aspect in the pathogenesis of GI involvement in SSc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SCLERODERMA; ESOPHAGUS; INVOLVEMENT; MOTILITY; SUBSETS; Endosonography; Systemic sclerosis; Gastrointestinal disorder |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Aug 2020 06:53 |
| Last Modified: | 10 Aug 2020 06:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25275 |
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