Renner, P. and Popp, F. C. and Eggenhofer, E. and Slowik, P. and Piso, P. and Geissler, E. K. and Schlitt, H. J. and Dahlke, M. H. (2010) Antigen-specific recognition is critical for the function of regulatory CD8(+)CD28(-) T cells. TRANSPLANT IMMUNOLOGY, 22 (3-4). pp. 144-149. ISSN 0966-3274,
Full text not available from this repository. (Request a copy)Abstract
The immunomodulatory properties of CD8 T cells with regulatory phenotype have become evident. It remains unclear whether the immurromodulatory function of CD8(+)CD28(-) T cells requires antigen-specific TCR interaction with major histocompatibility complex class I (MHC I). We have isolated naive CD8(+)CD28(-) T suppressor cells (Tsup) from H2-Kk Des-TCR mice that express a transgenic, MHC class I-restricted, clonotypic TCR against an allogeneic MHC class I molecule (H2-Kb) plus self-peptide. These cells were compared to B10.BR wild type (w/t) CD8(+)CD28(-) T cells and to naive CD4(+)CD25(+) regulatory T cells (Treg) of the same strains. Des CD8 effector T cells proliferated more readily when stimulated by H2-Kb splenocytes than w/t controls, whereas Des CD4 T cells showed the same alloresponse as w/t cells. Activation and proliferation of B10.BR CD4 T cells stimulated by H2-Kb APC were suppressed more effectively by Des CD8(+)CD28(-) T cells than by w/t CD8(+)CD28(-) T cells. On the contrary, Des CD4(+)CD25(+) T cells inhibited T cell proliferation less effectively than w/t CD4(+)CD25(+) T cells. In conclusion, we demonstrate that the function of naive Tsup is strongly enhanced by antigen recognition. Therefore we expect that Tsup are possible candidates for antigen-specific immurrosuppressive therapy. (C) 2009 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; ALLOGRAFT-REJECTION; SUPPRESSOR CELLS; DENDRITIC CELLS; ALPHA-CHAINS; IN-VITRO; LYMPHOCYTES; TRANSPLANTATION; GENERATION; TOLERANCE; CD8; CD28; T suppressor cells; T regulatory cells; TCR; MHC class I; Antigen recognition |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Aug 2020 07:26 |
| Last Modified: | 10 Aug 2020 07:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25281 |
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