Dietrich, Tina and Bock, Felix and Yuen, Don and Hos, Deniz and Bachmann, Bjoern O. and Zahn, Grit and Wiegand, Stanley and Chen, Lu and Cursiefen, Claus (2010) Cutting Edge: Lymphatic Vessels, Not Blood Vessels, Primarily Mediate Immune Rejections After Transplantation. JOURNAL OF IMMUNOLOGY, 184 (2). pp. 535-539. ISSN 0022-1767, 1550-6606
Full text not available from this repository. (Request a copy)Abstract
The purpose of this study was to determine the relative importance of blood vessels (hemangiogenesis) versus lymphatic vessels (lymphangiogenesis) in mediating immunological responses after transplantation. Using the murine model of corneal transplantation, graft survival was compared in differentially prevascularized and avascular recipient beds. Donor corneas (C57BL/6) were transplanted into uninflamed or inflamed avascular, prehemvascularized only or prehemvascularized and prelymphvascularized recipient murine eyes (BALB/C). Selective inhibition of lymphangiogenesis was achieved using antivascular endothelial growth factor receptor 3 Abs and anti-integrin alpha 5 small molecules. Grafts placed into only prehemvascularized recipient beds had a similarly good graft survival compared with grafts placed,into completely avascular, normal recipients, whereas the pre-existence of lymphatic vessels significantly deteriorated corneal graft survival (p < 0.05). Lymphatic vessels seem to contribute significantly to graft rejection after (corneal) transplantation. That may allow for selective, temporary, perioperative antilymphangiogenic treatment to promote graft survival without affecting blood vessels, even after solid organ transplantation. The Journal of Immunology, 2010, 184:535-539.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ORTHOTOPIC CORNEAL ALLOGRAFTS; INHIBITS LYMPHANGIOGENESIS; ANTERIOR-CHAMBER; GRAFT-REJECTION; RISK-FACTORS; MICE; BLOCKADE; NEOVASCULARIZATION; NEOANGIOGENESIS; HEMANGIOGENESIS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Aug 2020 08:44 |
| Last Modified: | 10 Aug 2020 08:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25302 |
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