Kommoss, S. and Rochon, J. and Harter, P. and Heitz, F. and Grabowski, J. P. and Ewald-Riegler, N. and Haberstroh, M. and Neunhoeffer, T. and Barinoff, J. and Gomez, R. and Traut, A. and du Bois, A. (2010) Prognostic Impact of Additional Extended Surgical Procedures in Advanced-Stage Primary Ovarian Cancer. ANNALS OF SURGICAL ONCOLOGY, 17 (1). pp. 279-286. ISSN 1068-9265, 1534-4681
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Treatment of advanced-stage ovarian carcinoma includes radical cytoreductive surgery, which aims at removing all visible tumor tissue followed by platinum and paclitaxel chemotherapy. Complete tumor resection may require extended surgical procedures. This paper reports on the prognostic impact of extensive surgery and surgical morbidity in patients with advanced-stage ovarian carcinoma. Patients with ovarian carcinoma [F,d,ration Internationale de Gyn,cologie et d'Obst,trique (FIGO) stage IIIB-IV] undergoing primary surgery in our tertiary gynecologic oncology unit between 1997 and 2007 were eligible for this study. The impact of established prognostic factors and the interaction with extent of surgical procedures on survival were assessed. A total of 267 patients aged between 29 and 88 years (median 64 years) were eligible for this study. Overall survival time was improved in patients who underwent complete tumor resection [hazard ratio (HR) 3.61 (1.91-6.61), P < 0.001]. No significant survival difference was observed between completely operated patients in whom extended or standard surgical procedures were applied [HR 1.37 (0.70-2.69), P = 0.358], and severe surgical complications were found to be equally distributed between the two patient groups. Our results may encourage the application of extended surgical procedures in patients who would otherwise be rendered incompletely debulked after primary cytoreduction. We could demonstrate an impact of complete tumor resection on patient prognosis and this was not traded off for extensive additional surgical morbidity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PRIMARY CYTOREDUCTIVE SURGERY; SURVIVAL; CARCINOMA; RESECTION; CRITIQUE; DISEASE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Aug 2020 06:39 |
| Last Modified: | 12 Aug 2020 06:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25355 |
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