Schmitz, Gerd and Ruebsaamen, Katharina (2010) Metabolism and atherogenic disease association of lysophosphatidylcholine. ATHEROSCLEROSIS, 208 (1). pp. 10-18. ISSN 0021-9150, 1879-1484
Full text not available from this repository. (Request a copy)Abstract
Lysophosphatidylcholine (LPC) is a major plasma lipid that has been recognized as an important cell signalling molecule produced under physiological conditions by the action of phospholipase A(2) on phosphatidylcholine. LPC transports glycerophospholipid components such as fatty acids, phosphatidylglycerol and choline between tissues. LPC is a ligand for specific G protein-coupled signalling receptors and activates several second messengers. LPC is also a major phospholipid component of oxidized low-density lipoproteins (Ox-LDL) and is implicated as a critical factor in the atherogenic activity of Ox-LDL. Hence, LPC plays an important role in atherosclerosis and acute and chronic inflammation. In this review we focus in some detail on LPC function, biochemical pathways, sources and signal-transduction system. Moreover, we outline the detection of LPC by mass spectrometry which is currently the best method for accurate and simultaneous analysis of each individual LPC species and reveal the pathophysiological implication of LPC which makes it an interesting target for biomarker and drug development regarding atherosclerosis and cardiovascular disorders. (C) 2009 Published by Elsevier Ireland Ltd.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LOW-DENSITY-LIPOPROTEIN; SECRETORY PHOSPHOLIPASE A(2); SMOOTH-MUSCLE-CELLS; PROTEIN-COUPLED RECEPTOR; ACTIVATING-FACTOR ACETYLHYDROLASE; MACROPHAGE CHOLESTEROL EFFLUX; THIN-LAYER-CHROMATOGRAPHY; TANDEM MASS-SPECTROMETRY; HUMAN ENDOTHELIAL-CELLS; FACTOR PAF RECEPTOR; Lysophospholipids; Lipidomics; Lipid species; Signalling; G protein-coupled receptor; Phospholipase |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 09 Apr 2020 07:50 |
| Last Modified: | 09 Apr 2020 07:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25366 |
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