Landfried, K. and Bataille, F. and Rogler, G. and Brenmoehl, J. and Kosovac, K. and Wolff, D. and Hilgendorf, I. and Hahn, J. and Edinger, M. and Hoffmann, P. and Obermeier, F. and Schoelmerich, J. and Andreesen, R. and Holler, Ernst (2010) Recipient NOD2/CARD15 status affects cellular infiltrates in human intestinal graft-versus-host disease. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 159 (1). pp. 87-92. ISSN 0009-9104, 1365-2249
Full text not available from this repository. (Request a copy)Abstract
P>Nucleotide-binding oligomerization domain 2/caspase recruitment domain 15 (NOD2/CARD15) polymorphisms have been identified as risk factors of both Crohn's disease and graft-versus-host disease (GVHD) following allogeneic stem cell transplantation. However, the role of these receptors of innate immunity in the pathophysiology of gastrointestinal GVHD is still poorly defined. Immunohistological features of intestinal GVHD were analysed in gastrointestinal biopsies from 58 patients obtained at the time of first onset of intestinal symptoms. The observed changes were correlated with concomitant risk factors and the presence of polymorphisms within the pathogen recognition receptor gene NOD2/CARD15. Intestinal GVHD was associated with a stage-dependent decrease in CD4 T cell infiltrates and an increase in CD8 T cells in the lamina propria; CD8 infiltrates correlated with extent of apoptosis and consecutive epithelial proliferation. The presence of NOD2/CARD15 variants in the recipient was associated with a significant loss of CD4 T cells: in a semiquantitative analysis, the median CD4 score for patients with wild-type NOD2/CARD15 was 1 center dot 1 (range 3), but only 0 center dot 4 (range 2) for patients with variants (P = 0 center dot 002). This observation was independent from severity of GVHD in multivariate analyses and could not be explained by the loss of forkhead box P3+ T cells. Our results suggest a loss of protective CD4 T cells in intestinal GVHD which is enhanced further by the presence of NOD2/CARD15 variants. Our study might help to identify more selective therapeutic strategies in the future.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFLAMMATORY-BOWEL-DISEASE; REGULATORY T-CELLS; CROHNS-DISEASE; DENDRITIC CELLS; TRANSPLANT RECIPIENTS; GVHD; EXPRESSION; MUTATIONS; VARIANTS; BIOPSY; CD4; gastrointestinal GVHD; immunohistology; NOD2; CARD15 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Aug 2020 13:25 |
| Last Modified: | 12 Aug 2020 13:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25407 |
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