Doenecke, Axel and Tsui, T-Y. and Zuelke, C. and Scherer, M. N. and Schnitzbauer, A. A. and Schlitt, H-J. and Obed, A. (2010) Pre-existent portal vein thrombosis in liver transplantation: influence of pre-operative disease severity. CLINICAL TRANSPLANTATION, 24 (1). pp. 48-55. ISSN 0902-0063,
Full text not available from this repository. (Request a copy)Abstract
Background: Portal vein thrombosis (PVT) is a surgical challenge in liver transplantation (LTx). In contrast to LTx in decompensated liver disease, which are associated with a higher morbidity and mortality, PVT influence on outcome is still under debate. To evaluate this influence at different stages of liver decompensation, we compared the outcome of patients suffering from PVT to patients with patent portal vein within different score ranges. Methods: We included 193 LTx (24 with PVT) in our study, transplanted between 2004 and 2007 at our institution. Patients were divided into four Model of End-Stage Liver Disease (MELD) score groups, and outcome was compared between PVT- and non-PVT patients. Results: In non-decompensated liver disease (MELD <15), we found a significantly decreased survival in patients suffering from PVT (one-yr survival 57% vs. 89%). By contrast, MELD score > 15 (decompensated liver disease) leads to an equal or even better survival in PVT- patients compared with patients without PVT (one-yr survival 91% vs. 75%), with an only slightly increased morbidity. Conclusion: Outcome in patients with PVT seems to be dependent on pre-operative disease severity. In contrast to compensated liver disease, no influence of PVT on outcome could be found in decompensated liver disease, and should therefore not be considered as a contraindication in LTx.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RISK-FACTORS; MANAGEMENT; ADULTS; ABNORMALITIES; MORTALITY; SURVIVAL; MELD; disease severity; liver transplantation; MELD score; portal vein thrombosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Aug 2020 05:43 |
| Last Modified: | 17 Aug 2020 05:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25416 |
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