Frick, Ulrich and Rehm, Juergen and Zullino, Daniele and Fernando, Manrique and Wiesbeck, Gerhard and Ammann, Jeannine and Uchtenhagen, Ambros (2010) Long-Term Follow-Up of Orally Administered Diacetylmorphine Substitution Treatment. EUROPEAN ADDICTION RESEARCH, 16 (3). pp. 131-138. ISSN 1022-6877,
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Background: To assess the long-term course of the feasibility and safety of orally administered heroin [diacetylmorphine (DAM)] tablets in substitution treatment of severely addicted opioid users. Design: Open-label, prospective cohort study with 2 non-randomly assigned treatment arms: DAM tablets only (n = 128) or DAM tablets combined with injected DAM and/or other opioids (n = 237). The average duration of the observation period was 62 months. Study endpoints were the time to discharge from treatment and the number of serious adverse events. Results: Both patient groups had a higher than 70% retention rate after the first 48 months of treatment, with similar long-term retention rates (after 8 years both groups had retention over 50%). The physician-verified rate of serious adverse events was 0.01 events per application year among the exclusively oral substitution group (intention-to-treat analysis) during the last year of observation, and 0.005 events per application year in the other group. Conclusions: Because of their feasibility and safety over years, DAM tablets may be a valuable long-term therapeutic alternative. Copyright (C) 2010 S. Karger AG, Basel
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MAINTENANCE TREATMENT; OPIOID DEPENDENCE; HEROIN; ADDICTS; METHADONE; PRESCRIPTION; MORPHINE; CANADA; TRIAL; USERS; Opioid dependence; Heroin substitution treatment; Oral application; Open-label study; Prospective cohort; Bias |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Aug 2020 06:33 |
| Last Modified: | 17 Aug 2020 06:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25439 |
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