Portilla-Arias, Jose and Patil, Rameshwar and Hu, Jinwei and Ding, Hui and Black, Keith L. and Garcia-Alvarez, Montserrat and Munoz-Guerra, Sebastian and Ljubimova, Julia Y. and Holler, Eggehard (2010) Nanoconjugate Platforms Development Based in Poly(beta,L-Malic Acid) Methyl Esters for Tumor Drug Delivery. JOURNAL OF NANOMATERIALS: 825363. ISSN 1687-4110, 1687-4129
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New copolyesters derived from poly(beta, L-malic acid) have been designed to serve as nanoconjugate platforms in drug delivery. 25% and 50% methylated derivatives (coPMLA-Me25H75 and coPMLA-Me50H50) with absolute molecular weights of 32 600 Da and 33 100 Da, hydrodynamic diameters of 3.0 nm and 5.2 nm and zeta potential of -15mV and -8.25mV, respectively, were found to destabilize membranes of liposomes at pH 5.0 and pH 7.5 at concentrations above 0.05mg/mL. The copolymers were soluble in PBS (half life of 40 hours) and in human plasma (half life of 15 hours) but they showed tendency to aggregate at high levels of methylation. Fluorescence-labeled copolymers were internalized into MDA-MB-231 breast cancer cells with increased efficiency for the higher methylated copolymer. Viability of cultured brain and breast cancer cell lines indicated moderate toxicity that increased with methylation. The conclusion of the present work is that partially methylated poly(beta, L-malic acid) copolyesters are suitable as nanoconjugate platforms for drug delivery.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POLY(BETA-L-MALIC ACID); PHYSARUM-POLYCEPHALUM; POLYMALATASE; DEGRADATION; ANTIBODIES; POLYMERS; CARRIER; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Alumni or Retired > Prof. Dr. Eggehard Holler |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Aug 2020 14:45 |
| Last Modified: | 17 Aug 2020 14:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25516 |
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