Spiegler, J. and Gilhaus, A. and Koenig, I. R. and Kattner, E. and Vochem, M. and Kuester, H. and Moeller, J. and Mueller, D. and Kribs, A. and Segerer, H. and Wieg, C. and Nikischin, W. and von der Wense, A. and Gebauer, C. and Herting, E. and Goepel, W. (2010) Polymorphisms in the Renin-Angiotensin System and Outcome of Very-Low-Birthweight Infants. NEONATOLOGY, 97 (1). pp. 10-14. ISSN 1661-7800,
Full text not available from this repository. (Request a copy)Abstract
Background: The insertion/ deletion polymorphism of the angiotensin-converting enzyme (ACE-ins/del) and the angiotensin II type 1 receptor 1166A/C polymorphism (ATR1166A/C) were reported to be associated with several unfavorable outcome parameters in preterm infants like bronchopulmonary dysplasia, persistent ductus arteriosus and impaired insulin sensitivity. Objective: To confirm the above-mentioned associations in a large cohort of very-low-birthweight (VLBW) infants. Method: Clinical data of VLBW infants were prospectively recorded. The ACE-ins/del polymorphism and the ATR1166A/C polymorphism were determined by polymerase chain reaction in 1,209 and 1,168 infants, respectively. Results: There was no significant association between ACE-ins/del or ATR1166A/C genotype and outcome parameters (death, intraventricular hemorrhage, sepsis, bronchopulmonary dysplasia, ventilation, supplemental oxygen at discharge, postnatal treatment with insulin, surgery for intestinal perforation/necrotizing enterocolitis/retinopathy of prematurity/persistent ductus arteriosus. Conclusion: Both known functional polymorphisms of the renin-angiotensin system do not seem to be associated with the outcome of VLBW infants. Copyright (C) 2009 S. Karger AG, Basel
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONVERTING ENZYME; PRETERM INFANTS; ACE; GENOTYPE; GENES; RISK; Bronchopulmonary dysplasia; Intraventricular hemorrhage; Persistent ductus arteriosus; Deletion/insertion polymorphism of the angiotensin-converting enzyme; Very-low-birthweight infants |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Aug 2020 05:56 |
| Last Modified: | 24 Aug 2020 05:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25548 |
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