del Rey, Adriana and Wolff, Christine and Wildmann, Johannes and Randolf, Anke and Straub, Rainer H. and Besedovsky, Hugo O. (2010) When Immune-Neuro-Endocrine Interactions Are Disrupted: Experimentally Induced Arthritis as an Example. NEUROIMMUNOMODULATION, 17 (3). pp. 165-168. ISSN 1021-7401,
Full text not available from this repository. (Request a copy)Abstract
We studied whether, in parallel to the activity of the hypothalamus-pituitary-adrenal axis and the sympathetic nervous system, hypothalamic cytokine expression and monoaminergic neurotransmitter concentrations are affected during the development and chronification of arthritis induced by immunization of rats with type II collagen. Corticosterone levels were increased only transiently, and were even below the normal range as the disease progressed. Increased adrenaline blood levels and hypothalamic IL-1 beta and IL-6 overexpression were observed only during the induction phase of the disease. The increase in hypothalamic noradrenaline content during the symptomatic phase was paralleled by a gradual loss of sympathetic fibers in the joints. Depletion of hypothalamic noradrenergic neurons at this time did not affect the symptomatology. Contrary to observations in healthy animals, no correlation between hypothalamic IL-1 beta expression and noradrenaline content was observed in rats with arthritis. The dissociation between hypothalamic cytokine gene expression and noradrenergic neuronal activity, the lack of sustained stimulation of the stress axes, and the loss of sympathetic signals in the joints indicate that the communication between afferent immune messages to the central nervous system and two main efferent anti-inflammatory pathways under control of the brain are disrupted during experimental arthritis. Copyright (C) 2010 S. Karger AG, Basel
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RHEUMATOID-ARTHRITIS; SYMPATHETIC-NERVE; BRAIN; SYSTEM; Arthritis; Hypothalamus-pituitary-adrenal axis; Sympathetic nervous system; Brain-borne cytokines; Neurotransmitters; Hypothalamus; Denervation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Aug 2020 06:10 |
| Last Modified: | 24 Aug 2020 06:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25563 |
Actions (login required)
 |
View Item |
