Mueller-Richter, Urs D. A. and Dowejko, Albert and Driemel, Oliver and Reuther, Tobias and Reichert, Torsten E. and Kubler, Alexander C. (2010) Impact of MAGE-A antigens on taxane response in oral squamous cell carcinoma. ONCOLOGY LETTERS, 1 (1). pp. 181-185. ISSN 1792-1074,
Full text not available from this repository.Abstract
MAGE-A antigens are a subgroup of cancer/testis antigens that are exclusively expressed in malignant cells Only scarce information on the function of MAGL-A antigens is available There is some evidence that they may influence the response to chemotherapeutic drugs This study aimed to evaluate the impact of the MAGE-A antigen subgroups MAGE-A2, -A3, -A4 and -A6 on oral squamous cell carcinoma cell lines treated with docetaxel and paclitaxel Five oral squamous cell carcinoma cell lines were characterized for their quantitative expression of MAGE-A2, -A3, -A4 and -A6 The cell lines were treated with concentrations ranging from 0 025 to 0 8 mu M of docetaxel and paclitaxel The amount of viable cells after 24 and 48 h was measured The measurements were statistically correlated with MAGE-A expression All cell lines responded to docetaxel and paclitaxel One cell line showed a statistically significant weaker response to the taxa ne treatment This cell line was the only one that expressed MAGE-A4 MAGE-A4 has a statistically significant impact on the tumour response to docetaxel and paclitaxel in oral squamous cell carcinoma This may influence treatment options and the course of the disease Therefore, patients should be evaluated for MAGE-A4 expression before treatment with taxanes
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NORMAL-TISSUES; EXPRESSION; CANCER; GENES; NECK; HEAD; RESISTANCE; TAXOTERE; TAXOL; MAGE-A antigens; chemotherapy; taxanes; oral squamous cell carcinoma; tumour antigens |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Aug 2020 06:44 |
| Last Modified: | 24 Aug 2020 06:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25571 |
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