Meyer, Stefanie and Vogt, Thomas and Landthaler, Michael and Berand, Anna and Reichle, Albrecht and Bataille, Frauke and Marx, Andreas H. and Menz, Anne and Hartmann, Arndt and Kunz-Schughart, Leoni A. and Wild, Peter J. (2010) Cyclooxygenase 2 (COX2) and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) Are Stage-Dependent Prognostic Markers of Malignant Melanoma. PPAR RESEARCH: 848645. ISSN 1687-4757, 1687-4765
Full text not available from this repository. (Request a copy)Abstract
Using tissue microarrays (TMAs) we studied COX2/PPARG immunoreactivity in a broad spectrum of tumors focussing on clinicopathological correlations and the outcome of patients with malignant melanoma (MM). TMA-1 contained normal and tumor tissues (n = 3448) from 47 organs including skin neoplasms (n = 323); TMA-2 88 primary MM, 101 metastases, and 161 benign nevi. Based on a biomodulatory approach combining COX/PPAR-targeting with metronomic low-dose chemotherapy metastases of 36 patients participating in a randomized trial with metastatic (stage IV) melanoma were investigated using TMA-3. COX2/PPARG immunoreactivity significantly increased from nevi to primary MM and metastases; COX2 positivity was associated with advanced Clark levels and shorter recurrence-free survival. Patients with PPARG-positive metastases and biomodulatory metronomic chemotherapy alone or combined with COX2/PPARG-targeting showed a significantly prolonged progression-free survival. Regarding primary MM, COX2 expression indicates an increased risk of tumor recurrence. In metastatic MM, PPARG expression may be a predicitive marker for response to biomodulatory stroma-targeted therapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OVARIAN-CARCINOMA; BREAST-CANCER; TUMOR-STROMA; EXPRESSION; TISSUE; CELLS; AGONISTS; ROFECOXIB; THERAPY; DRUGS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Aug 2020 08:34 |
| Last Modified: | 24 Aug 2020 08:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25607 |
Actions (login required)
 |
View Item |
