Paulus, Christina and Nitzsche, Alexandra and Nevels, Michael (2010) Chromatinisation of herpesvirus genomes. REVIEWS IN MEDICAL VIROLOGY, 20 (1). pp. 34-50. ISSN 1052-9276, 1099-1654
Full text not available from this repository. (Request a copy)Abstract
The double-stranded DNA genomes of herpesviruses, exist in at least three alternative global chromatin states characterised by distinct nucleosome content. When encapsidated in virus particles, the viral DNA is devoid of any nucleosomes. In contrast, within latently infected nuclei herpesvirus genomes are believed to form regular nucleosomal structures resembling cellular chromatin. Finally, during productive infection nuclear viral DNA appears to adopt a state of intermediate chromatin formation with irregularly spaced nucleosomes. Nucleosome occupancy coupled with post-translational histone modifications and other epigenetic marks may contribute significantly to the extent and timing of transcription from the viral genome and, consequently, to the outcome of infection. Recent research has provided first insights into the viral and cellular mechanisms that either maintain individual herpesvirus chromatin states or mediate transition between them. Here, we summarise and discuss both early work and new developments pointing towards common principles pertinent to the dynamic structure and epigenetic regulation of herpesvirus chromatin. Special emphasis is given to the emerging similarities in nucleosome assembly and disassembly processes on herpes simplex virus type I and human cytomegalovirus genomes over the course of the viral productive replication cycle and during the switch between latent and lytic infectious stages. Copyright (C) 2009 John Wiley & Sons, Ltd.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SIMPLEX-VIRUS TYPE-1; IMMEDIATE-EARLY PROTEIN; EPSTEIN-BARR-VIRUS; CYTOMEGALOVIRUS GENE-EXPRESSION; SARCOMA-ASSOCIATED HERPESVIRUS; SAGA-ACETYLATED NUCLEOSOMES; INTRINSIC IMMUNE DEFENSE; INFECTED CELL PROTEIN-0; NUCLEAR DOMAIN 10; LYTIC INFECTION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Petra Gürster |
| Date Deposited: | 07 Apr 2020 10:29 |
| Last Modified: | 07 Apr 2020 10:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25618 |
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