Auerswald, Steffen and Schreml, Stephan and Meier, Robert and Blancke Soares, Alexandra and Niyazi, Maximilian and Marschner, Sebastian and Belka, Claus and Canis, Martin and Haubner, Frank (2019) Wound monitoring of pH and oxygen in patients after radiation therapy. RADIATION ONCOLOGY, 14 (1): 199. ISSN 1748-717X
Full text not available from this repository. (Request a copy)Abstract
Objectives Postradiogenic wound healing disorders are an important clinical problem. While a variety of treatment modalities are available, there is no strategy to objectively judge treatment success. The aim of this study was to evaluate a 2D luminescence imaging system for pH and oxygen in non-healing wounds after radiotherapy. Methods Luminescence 2D imaging was performed with the VisiSens (Presens, Regensburg, Germany) 2D imaging systems A1 and A2 for oxygen and pH, respectively. Biocompatible planar luminescent sensor foils were applied to non-irradiated and irradiated skin as well as to radiogenic wounds of five patients and the pH and the oxygen saturation was determined. Results pH measurements showed significant differences between non-irradiated skin (6.46 +/- 0.18) and irradiated skin (6.96 +/- 0.26). Radiogenic wounds exhibited the highest pH values (7.53 +/- 0.26). Oxygen measurements revealed a mean oxygen saturation of non-irradiated skin of 6.19 +/- 0.83 mmHg. The highest value of oxygen saturation (28.4 +/- 2.4 mmHg) was found on irradiated skin while irradiated wounds had a poor oxygen saturation (9.4 +/- 2.2 mmHg) (mean +/- s.e.m.). Conclusion We found that routine measurement of pH and pO2 in patients could be easily integrated into the clinical routine. The results of the measurements show unfavorable pH and oxygen saturation conditions for wound healing in irradiated wounds. Interestingly, irradiated wounds exhibit a more pronounced hypoxia than irradiated skin which is reflected by an altered pH and pO2 compared to unirradiated skin, which has the potential to serve as a prognostic marker in the future. In addition to the objectification of the treatment success of postradiogenic wound healing disorders, the extent of skin toxicity could already be predicted during radiotherapy with this method.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VACUUM-ASSISTED CLOSURE; HUMAN STRATUM-CORNEUM; NECK REGION; IN-VIVO; HEAD; PROLIFERATION; RADIOTHERAPY; MIGRATION; GRADIENT; IMPACT; Wound healing; Radiotherapy; Luminescence; pH; Oxygen |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Mar 2020 10:43 |
| Last Modified: | 22 Jul 2021 12:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25838 |
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