Evers, Katrina Suzanne and Huhn, Evelyn Annegret and Fouzas, Sotirios and Barro, Christian and Kuhle, Jens and Fisch, Urs and Bernasconi, Luca and Lapaire, Olav and Wellmann, Sven (2019) Impact of parturition on maternal cardiovascular and neuronal integrity in a high risk cohort - a prospective cohort study. BMC PREGNANCY AND CHILDBIRTH, 19 (1): 403. ISSN , 1471-2393
Full text not available from this repository. (Request a copy)Abstract
Background To better understand the profound multisystem changes in maternal physiology triggered by parturition, in particular in the underexplored neuronal system, by deploying a panel of pre- vs post-delivery maternal serum biomarkers, most notably the neuronal cytoskeleton constituent neurofilament light chain (NfL). This promising fluid biomarker is not only increasingly applied to investigate disease progression in numerous brain diseases, particularly in proteopathies, but also in detection of traumatic brain injury or monitoring neuroaxonal injury after ischemic stroke. Methods The study was nested within a prospective cohort study of pregnant women at risk of developing preeclampsia at the University Hospital of Basel. Paired ante- and postpartum levels of progesterone, soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), mid-regional pro-atrial natriuretic peptide (MR-proANP), copeptin (CT-proAVP), and NfL were measured in 56 women with complete clinical data. Results Placental delivery significantly decreased all placental markers: progesterone 4.5-fold, PlGF 2.2-fold, and sFlt-1 1.7-fold. Copeptin and MR-proANP increased slightly (1.4- and 1.2-fold, respectively). Unexpectedly, NfL levels (median [interquartile range]) increased significantly post-partum: 49.4 (34.7-77.8) vs 27.7 (16.7-31.4) pg/ml (p < 0.0001). Antepartum NfL was the sole independent predictor of NfL peri-partum change; mode of delivery, duration of labor, clinical characteristics and other biomarkers were all unrelated. Antepartum NfL levels were themselves independently predicted only by maternal age. Conclusions Parturition per se increases maternal serum NfL levels, suggesting a possible impact of parturition on maternal neuronal integrity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NATRIURETIC-PEPTIDE; NEUROFILAMENT LIGHT; GROWTH-FACTOR; PREGNANCY; SERUM; COPEPTIN; WOMEN; BIOMARKERS; PRECURSOR; DELIVERY; Parturition; Brain; Delivery; Pregnancy; Birth; Surrogate marker |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Mar 2020 12:38 |
| Last Modified: | 24 Mar 2020 12:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25862 |
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