Unterbuchner, C. and Ehehalt, K. and Graf, B. (2019) Algorithm-based preventive strategies for avoidance of residual neuromuscular blocks. ANAESTHESIST, 68 (11). pp. 744-754. ISSN 0003-2417, 1432-055X
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Background Postoperative residual neuromuscular block (train of four ratio <0.9) is an outcome-relevant problem in balanced anesthesia, which increases postoperative morbidity and mortality. Implementation of medium and short-acting muscle relaxants, quantitative neuromuscular monitoring and pharmacological reversal of muscle relaxation reduce the incidence of residual neuromuscular block. The question arises whether this is suitable to create a pragmatic algorithm integrating these three individual methods to reduce paralysis-associated complications? Methods A selective literature search was carried out in PubMed and guidelines of national specialist societies were searched using special terms. Results The incidence of residual neuromuscular block varied among the studies but was as high as 93%. Using calibrated acceleromyography it is possible to identify a residual relaxation with a negative predictive value of 97% (95% confidence interval, CI 83-100%). Reversal by administration of the acetylcholinesterase inhibitor neostigmine reduces the incidence of residual neuromuscular block to 15.4%, in combination with calibrated acceleromyography to 3.3%. Reversal with sugammadex can nearly completely eliminate residual neuromuscular block. Quantitative neuromuscular monitoring and pharmacological reversal can be suitably integrated into a stage-based, pragmatic treatment algorithm. Conclusion The algorithm-based concept of quantitative neuromuscular monitoring and pharmacological reversal using neostigmine and sugammadex enables residual neuromuscular block to be treated within 10min before extubation of the patient. Ongoing educational programs are essential for implementation of modern muscle relaxant management concepts. Quantitative neuromuscular monitoring should be mandatory for all patients receiving neuromuscular blocking drugs. It would be desirable that German-speaking societies for anesthesiology make appropriate recommendations in guidelines.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ADDUCTOR POLLICIS MUSCLE; DOUBLE-BURST STIMULATION; GENERAL-ANESTHESIA; TRAIN-OF-4 RATIO; CARE-UNIT; SPONTANEOUS-RECOVERY; RESPIRATORY EVENTS; PERIOPERATIVE MANAGEMENT; NEOSTIGMINE REVERSAL; INCOMPLETE REVERSAL; Muscle relaxants; Neuromuscular monitoring; Sugammadex; Neostigmine; Acceleromyography |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Mar 2020 08:30 |
| Last Modified: | 25 Mar 2020 08:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25975 |
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