Zhu, Xinzhou and Yan, Jingyi and Bregere, Catherine and Zelmer, Andrea and Goerne, Tessa and Kapfhammer, Josef P. and Guzman, Raphael and Wellmann, Sven (2019) RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury. NATURE COMMUNICATIONS, 10: 3983. ISSN 2041-1723,
Full text not available from this repository. (Request a copy)Abstract
Hypoxic ischemia (HI) is an acute brain threat across all age groups. Therapeutic hypothermia ameliorates resulting injury in neonates but its side effects prevent routine use in adults. Hypothermia up-regulates a small protein subset that includes RNA-binding motif protein 3 (RBM3), which is neuroprotective under stressful conditions. Here we show how RBM3 stimulates neuronal differentiation and inhibits HI-induced apoptosis in the two areas of persistent adult neurogenesis, the subventricular zone (SVZ) and the subgranular zone (SGZ), while promoting neural stem/progenitor cell (NSPC) proliferation after HI injury only in the SGZ. RBM3 interacts with IGF2 mRNA binding protein 2 (IMP2), elevates its expression and thereby stimulates IGF2 release in SGZ but not SVZ-NSPCs. In summary, we describe niche-dependent regulation of neurogenesis after adult HI injury via the novel RBM3-IMP2-IGF2 signaling pathway.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RNA-BINDING PROTEIN; NEURAL STEM-CELLS; THERAPEUTIC HYPOTHERMIA; HIPPOCAMPAL NEUROGENESIS; MOTIF PROTEIN-3; IGF-II; EXPRESSION; MAINTENANCE; PRESERVES; FOREBRAIN; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Apr 2020 09:38 |
| Last Modified: | 06 Apr 2020 09:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26276 |
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