Foertsch, Sandra and Lackner, Ina and Weber, Birte and Fuechsl, Andrea M. and Langgartner, Dominik and Wirkert, Eva and Peters, Sebastian and Fois, Giorgio and Pressmar, Jochen and Fegert, Joerg M. and Frick, Manfred and Guendel, Harald and Kalbitz, Miriam and Reber, Stefan O. (2019) Sensory contact to the stressor prevents recovery from structural and functional heart damage following psychosocial trauma. BRAIN BEHAVIOR AND IMMUNITY, 80. pp. 667-677. ISSN 0889-1591, 1090-2139
Full text not available from this repository. (Request a copy)Abstract
Cardiovascular disorders (CVD) and posttraumatic stress disorder (PTSD) are highly comorbid, but the underlying mechanisms are not fully understood. Chronic psychosocial stress was induced in male mice by chronic subordinate colony housing (CSC), a pre-clinically validated mouse model for PTSD. Cardiac structure and function were assessed on day 20 of the CSC paradigm. Following CSC, mice were kept in different sensory contact modalities to the last aggressor for 30 days, and development of cardiac function and behavioral aspects were determined. Here we show that psychosocial trauma affects heart structure by disturbing cell-to-cell integrity of cardiomyocytes, causes tachycardia, disturbance of diurnal heart rate rhythmicity and behavioral deficits in a mouse model for PTSD. Structural and functional alterations were also found in cardiomyocytes upon in vitro treatment with pro-inflammatory cytokines typically increased after psychosocial trauma. Interestingly, sensory contact to the aggressor subsequent to psychosocial trauma prohibits functional and structural heart recovery, while isolation was beneficial for cardiac but detrimental for mental health. These findings contribute to our understanding of potential mechanisms underlying the high comorbidity of CVD and PTSD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFLAMMATORY MARKERS; DISORDER; ANXIETY; MICE; CONNEXIN-43; PREVALENCE; EXPRESSION; CELLS; VULNERABILITY; COMORBIDITY; Chronic psychosocial trauma; Chronic subordinate colony housing; Posttraumatic stress disorder; Cardiac damage; Sensory contact; Social anxiety |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Frank Schweda |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Apr 2020 07:18 |
| Last Modified: | 01 Apr 2020 07:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26553 |
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