Goetz, Th I. and Schmidkonz, C. and Lang, E. W. and Maier, A. and Kuwert, T. and Ritt, P. (2019) Factors affecting accuracy of S values and determination of time-integrated activity in clinical Lu-177 dosimetry. ANNALS OF NUCLEAR MEDICINE, 33 (7). pp. 521-531. ISSN 0914-7187, 1864-6433
Full text not available from this repository. (Request a copy)Abstract
IntroductionIn any radiotherapy, the absorbed dose needs to be estimated based on two factors, the time-integrated activity of the administered radiopharmaceutical and the patient-specific dose kernel. In this study, we consider the uncertainty with which such absorbed dose estimation can be achieved in a clinical environment.MethodsTo calculate the total error of dose estimation we considered the following aspects: The error resulting from computing the time-integrated activity, the difference between the S-value and the patient specific full Monte Carlo simulation, the error from segmenting the volume-of-interest (kidney) and the intrinsic error of the activimeter.ResultsThe total relative error in dose estimation can amount to 25.0% and is composed of the error of the time-integrated activity 17.1%, the error of the S-value 16.7%, the segmentation error 5.4% and the activimeter accuracy 5.0%.ConclusionErrors from estimating the time-integrated activity and approximations applied to dose kernel computations contribute about equally and represent the dominant contributions far exceeding the contributions from VOI segmentation and activimeter accuracy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ITERATIVE RECONSTRUCTION METHODS; PATIENT-SPECIFIC DOSIMETRY; RADIONUCLIDE THERAPY; RADIATION-DOSIMETRY; MONTE-CARLO; MODEL; Lu-177 dosimetry; S-values; Time integrated activity; Monte Carlo simulations; SPECT; CT |
| Subjects: | 500 Science > 530 Physics |
| Divisions: | Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Elmar Lang |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Apr 2020 09:52 |
| Last Modified: | 07 Apr 2020 09:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26741 |
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