Stoehr, Christine G. and Steffens, Sandra and Polifka, Iris and Jung, Rudolf and Kahlmeyer, Andreas and Ivanyi, Philipp and Weber, Florian and Hartmann, Arndt and Wullich, Bernd and Wach, Sven and Taubert, Helge (2019) Piwi-like 1 protein expression is a prognostic factor for renal cell carcinoma patients. SCIENTIFIC REPORTS, 9: 1741. ISSN 2045-2322,
Full text not available from this repository. (Request a copy)Abstract
The Piwi-like genes belong to the Argonaute gene family and are conserved in plants, animals and humans. In addition to their essential role in the germ line and as stem cell-associated genes, Piwi-like proteins play a role in different cancer types but have yet to be studied in renal cell carcinoma (RCC). We investigated tissue micro arrays (TMAs) with tumor samples of two independent cohorts of RCC patients (N = 265 and N = 345); we used immunohistochemistry to assess the protein expression of Piwi-like 1. Applying an immunoreactive score (IRS), we found Piwi-like 1 positivity (IRS > 0) in 28.3% and 14.8% of the tumors in cohorts 1 and 2, respectively. Piwi-like 1 positivity was correlated with Fuhrman grade, tumor stage and the presence of distant metastasis (P < 0.005). Moreover, in univariate and multivariate analyses (adjusted to Fuhrman grade and tumor stage), Piwi-like 1 positivity was associated with a shorter cancer-specific survival in the patients in the second cohort. In addition, Piwi-like 1 expression allowed to further distinguish the RCC patients with high Fuhrman grade, high tumor stage, distant metastasis or high pre-operative levels of C-reactive protein, as Piwi-like 1 positivity was associated with a shorter cancer-specific survival in both cohorts. Our data encourage further investigations to enlighten the role of Piwi-like 1 and its function as a marker of poor prognosis in RCC patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STEM-CELLS; ARGONAUTE FAMILY; HIWI GENE; CANCER; RECEPTORS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Apr 2020 11:25 |
| Last Modified: | 17 Apr 2020 11:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27553 |
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